Effect of ulinastatin combined with anti-infective therapy on systemic inflammatory response and oxidative stress response in patients with acute severe pneumonia

摘要

Objective: To study the effect of ulinastatin combined with anti-infective therapy on systemic inflammatory response and oxidative stress response in patients with acute severe pneumonia. Methods: A total of 50 patients with acute severe pneumonia who were treated in the hospital between September 2014 and December 2016 were collected and divided into control group and observation group according to the random number table method, 25 cases in each group. Control group received conventional therapy, and the observation group received ulinastatin combined with conventional therapy. The differences in inflammatory response and oxidative stress response in serum were measured before treatment and 10 d after treatment. Results:Before treatment, differences in serum levels of inflammatory response indexes and oxidative stress indexes were not statistically significant between the two groups. After treatment, serum IL-2, IL-6, PCT, HMGB1, CRP, IL-4, IL-10, IL-13, MDA, AOPP and ROS levels of both groups of patients were lower than those before treatment while SOD, T-AOC, GSH-Px and LHP levels were higher than those before treatment, and serum IL-2, IL-6, PCT, HMGB1, CRP, IL-4, IL-10, IL-13, MDA, AOPP and ROS levels of observation group were lower than those of control group while SOD, T-AOC, GSH-Px and LHP levels were higher than those of control group. Conclusion: Ulinastatin combined with anti-infective therapy can effectively reduce the systemic inflammatory response and oxidative stress response and optimize the overall condition in patients with acute severe pneumonia.