Study on the correlation of serum inflammatory cytokine and insulin-like growth factor related indicators with hypertensive disorder complicating pregnancy

摘要

Objective:To explore the correlation of serum inflammatory cytokine and insulin-like growth factor (IGF) related indicators with hypertensive disorder complicating pregnancy (HDP). Methods:A total of 90 patients with HDP who were admitted in our hospital from July, 2015 to July, 2016 for delivery were included in the study and divided into the pregnancy-induced hypertension group (n=43), mild preeclampsia group (n=28), and severe preeclampsia group (n=19). Moreover, 40 healthy puerpera who were admitted in the same period for delivery were served as the control group. The peripheral venous blood before delivery was collected. The immunoturbidimetry was used to detect hs-CRP. The radioimmunoassay was used to detect TNF-α and IL-6. ELISA was used to detect IGF-I, IGF-II, and IGFBP-1.Results:The serum hs-CRP, TNF-α, and IL-6 levels in the pregnancy-induced hypertension group, mild preeclampsia group, and severe preeclampsia group were significantly higher than those in the control group, and were gradually elevated with the further aggravation of the disease. The serum IGF-I and IGF-II levels in the pregnancy-induced hypertension group, mild preeclampsia group, and severe preeclampsia group were significantly lower than those in the control group, while IGFBP-1 level was significantly higher than that in the control group. With the further aggravation of the disease, IGF-I and IGF-II levels were gradually reduced, while IGFBP-1 level was gradually elevated.Conclusions: hs-CRP, TNF-α, IL-6, IGF-Ⅰ, IGF-Ⅱ, and IGFBP-1 are closely associated with the occurrence and development of HDP.