Correlation of serum free fatty acid content with glucolipid metabolism, microinflammation and oxidative stress state in patients with type 2 diabetes mellitus

摘要

Objective: To investigate the correlation of serum free fatty acid content with glucolipid metabolism, microinflammation and oxidative stress state in patients with type 2 diabetes mellitus. Methods: A total of 189 patients with type 2 diabetes mellitus who were treated in this hospital between August 2015 and February 2018 were chosen as type 2 diabetes mellitus group, and 100 healthy subjects who received physical examination in this hospital during the same period were chosen as the normal control group. The differences in serum levels of FFA, glucolipid metabolism indexes, microinflammation indexes and oxidative stress indexes were compared between the two groups of subjects, and correlation analysis was adopted to judge the inner link of serum FFA content with glucolipid metabolism, microinflammation and oxidative stress state in patients with type 2 diabetes mellitus. Results: Serum FFA content of type 2 diabetes mellitus group was higher than that of control group; serum glucolipid metabolism indexes FPG, 2hPG, TC and LDL-C levels were higher than those of normal control group whereas HDL-C level was lower than that of control group; serum microinflammation indexes IL-1β, IL-6, IL-10, IL-15 and TNF-α contents were higher than those of control group; serum oxidative stress indexes GSH-Px and SOD contents were lower than those of control group whereas ROS and MDA contents were higher than those of control group. Pearson test showed that the serum FFA content of patients with type 2 diabetes mellitus was directly correlated with the contents of glucolipid metabolism, microinflammation and oxidative stress indexes. Conclusion: Serum FFA content significantly increases in patients with type 2 diabetes mellitus, and the specific content was directly correlated with glycolipid metabolism, microinflammation, oxidative stress and other illness indexes.