Effect of uterine water bag + gauze packing on coagulation function and stress response of patients with postpartum hemorrhage

摘要

Objective:To study the effect of uterine water bag + gauze packing on coagulation function and stress response of patients with postpartum hemorrhage.Methods: Patients who gave birth and had postpartum hemorrhage in the hospital between June 2014 and May 2017 were chosen as the research subjects and divided into the combined group who received uterine water bag + gauze packing hemostasis, the control group 1 who received uterine water bag hemostasis and the control group 2 who received gauze packing hemostasis. The overall clinical efficacy was observed, and the serum levels of blood coagulation function indexes and stress response indexes were determined before treatment and after hemostatic treatment.Results: The intraoperative blood loss, postoperative blood loss and the change of hemoglobin before treatment and after hemostatic treatment of combined group were less than those of control group 1 and control group 2; compared with those of same group before treatment, serum APTT and PT levels as well as FDP, ET-1, ANG-II, ALD, NE, E, TNF-α, IL-6, ICAM1 and VCAM1 contents after hemostatic treatment were significantly lower whereas PAI-1 and AT-III contents were significantly higher, and serum APTT and PT levels as well as FDP, ET-1, ANG-II, ALD, NE, E, TNF-α, IL-6, ICAM1 and VCAM1 contents of combined group after hemostatic treatment were significantly lower than those of control group 1 and control group 2 whereas PAI-1 and AT-III contents were significantly higher than those of control group 1 and control group 2.Conclusion: uterine water bag + gauze packing treatment of postpartum hemorrhage can achieve better efficacy than monotherapy and improve the coagulation function and stress response.