宫外发育迟缓早产儿部分生化代谢指标分析

摘要

Objective:To investigate the changes of biochemical and metabolic indices in premature infants with extrauterine growth retardation (EUGR).Methods:Sixty premature infants are categorized into EUGR group and non-EUGR group.Physical indices (body weight,body length and head circumference) were detected in 7 d,14 d,3 and 6 months after birth,and at the same time fasting peripheral venous blood was drawn to examine the levels of albumin (ALB),prealbumin (PA),cholesterol (TC),triglyceride (TG),high density lipoprotein-cholesterol (HDL-C),low density lipoprotein-cholesterol (LDL-C),fasting blood glucose (FBG),insulin,C-peptide (CP),insulin-like growth factor (IGF-I),and insulin resistance index (IRI) was calculated.Results:The body weight of EUGR group infants was lower than non-EUGR group at 7 d and 14 d after birth (P ＜0.05);body weight,head circumference and body length of EUGR group infants were lower than non-EUGR group at 3 and 6 months after birth (P ＜ 0.05).The growth retardation rates of weight,head circumference and body length of EUGR group infants were higher than that of non-EUGR group at 3 and 6 months after birth (P ＜ 0.05).The level of PA of EUGR group was lower than that of non-EUGR group at 7 d,14 d,3 and 6 months after birth;the level of IGF-1 of EUGR group was lower than that of non-EUGR group at 3 and 6 months after birth (P ＜ 0.05),the levels of PA and IGF-1 of all the groups tended to increase along with age increasing.The level of INS of EUGR group was higher than that of non-EUGR group at 3 months after birth (P ＜ 0.05);Occurrence of insulin resistance (IR) in EUGR group was higher than non-EUGR group in 3 months after birth (P ＜ 0.05).Conclusions:The levels of PA、IGF-1 and IR are closely related to the EUGR of premature infant.%目的:探讨宫外发育迟缓(EUGR)早产儿生化代谢指标的变化.方法:60例早产儿分为EUGR组及非EUGR组,于出生后7、14 d、3月龄、6月龄4个时间点测量两组早产儿的体格指标(体质量、身长、头围),并于同一时间点清晨取空腹外周静脉血检测清蛋白(ALB)、前清蛋白(PA)、胆固醇(TC)、三酰脂甘油(rG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)、INS、C肽、IGF-1,计算胰岛素抵抗指数(IRI).结果:EUGR组7、14 d体质量低于非EUGR组,3月龄、6月龄体质量、头围、身长低于非EUGR组,体质量、头围及身长落后比例高于非EUGR组,差异有统计学意义(P＜ 0.05);EUGR组7、14 d、3月龄、6月龄PA水平低于非EUGR组早产儿,3月龄、6月龄IGF-1水平低于非EUGR组,差异有统计学意义(P＜0.05),两组新生儿PA、IGF-1水平随日龄增加有升高趋势;3月龄logINS高于非EUGR组,发生胰岛素抵抗(IR)的例数多于非EUGR组,差异有统计学意义(P＜0.05).结论:早产儿EUGR与PA水平、IGF-1水平和IR密切相关.