双氢青蒿素和奎宁对恶性疟原虫早期配子体作用的随机比较

摘要

【目的】研究双氢青蒿素对恶性疟原虫早期配子体的抑杀作用。【方法】仅骨髓带恶性疟原虫早期配子体而骨髓与外周血液均无成熟配子体的患者11例，随机分为A、B2组。A组6例口服双氢青蒿素片7d总量480mg；B组5例口服硫酸奎宁片7d总量10500mg，定时取骨髓和外周血液涂片，观察两组配子体密度的变化。【结果】A组骨髓早期配子体药后10d全部转阴；而B组全部阳性，至药后14d仍有2/5例阳性。外周血液配子体转阴时间，A组为(4.8±0.9)d；B组为(22.0±5.8)d。【结论】双氢青蒿素能杀灭恶性疟原虫早期配子体，而硫酸奎宁似无此作用。%【Objective】To study the effects of dihydroartemisinin and quinineo n plasmodium falciparum gametocytes at early stage.【Methods】Eleven patients wi th falciparum malaria who had plasmodium falciparum gametocytes at early stage(P FGe) in bone marrow but no matured plasmodium falciparum gametocytes(PFGm) in bo ne marrow and peripheral blood were allocated to two groups.Group A(n=6) were ad ministered orally with dihydroartemisinin at a total dosage of 480mg for 7 days and Group B(n=5) with quinine sulfate at a total dosage of 10500 mg for 7 days .T he number of gametocytes in bone marrow and peripheral blood was examined at reg ular time.【Results】 PFGe in bone marrow disappeared in Group A on 10th day a fter the first administration while existed in all the cases of Group B on 10 th day and still in 2 cases on 14th day.The clearance time for periphe ral PFGe was 4.8±0.9 days in Group A and 22.0±5.8 days in Group B.【Conclusion】Dihydroartemisinin can clear PFGe but quinine sho ws no this action.