脑康颗粒治疗脑卒中后轻度认知功能障碍的临床观察

摘要

[目的]观察补益肝肾、活血化瘀、化痰开窍制剂脑康颗粒治疗卒中后轻度认知功能障碍髓海不足型患者的临床疗效.[方法]将60例卒中后认知障碍患者随机分为治疗组和对照组各30例,治疗组给予脑康颗粒治疗,对照组给予尼莫地平治疗,2组疗程均为6周.选择简明精神状态量表(MMSE)、蒙特利尔量表(MoCA)为疗效评价标准进行疗效比较.[结果]治疗后,治疗组的总有效率为66.67％,对照组为53.33％,2组疗效接近,差异无统计学意义(P＞0.05).治疗后2组的MMSE评分、MoCA评分均较治疗前显著改善(均P＜0.01),且MoCA评分治疗组优于对照组(P＜0.01).[结论]脑康颗粒能有效提高卒中后轻度认知功能障碍髓海不足型患者的认知功能水平.%Objective To observe the therapeutic effect of Naokang Granula,a Chinese herbal patent with the actions of tonifying liver and kidney,activating blood and removing stasis,resolving phlegm and inducing resuscitation for the treatment of post-stroke mild cognitive impairment with insufficiency of marrow-reservoir.Methods Randomized controlled trial was adopted,and 60 patients with post-stroke cognitive impairment were equally divided into treatment group and control group.The control group received oral administration of Nimodipine tablets while the treatment group was treated with Naokang Granula.Both groups were treated for 6 weeks.A comparison of therapeutic effect was made in both groups before and after treatment by mini-mental state examination (MMSE) and Montreal cognitive assessment scale (MoCA).Results After treatment,the treatment group had a total effective rate of 66.67％,and the control group had a total effective rate of 53.33％.The effective rate in the two groups had no significant difference (P＞0.05).The scores of MMSE and MoCA were improved in both groups after treatment (P＜0.01 compared with those before treatment),and the improvement of MoCA in the treatment group was superior to that in the control group (P＜0.01).Conclusion Naokang Granula is effective on improving cognitive function in patients with post-stroke mild vascular cognitive impairment with insufficiency of marrow-reservoir.