地高辛对全因死亡率影响的荟萃分析

摘要

Objective:To investigate the effect of Digoxin on rate of all-cause mortality by meta-analysis. Methods:The articles were collected from Medline and Cochrane databases. Heterogeneity was analyzed by I2 statistics. The risk of Digoxin on all-cause mortality was analyzed by random effect model to give the hazard ratio ( HR) of combined effect indicators and its 95% confidence interval. Results:Ten studies were included finally, with a total sample size of 24865. There was no significant difference in the risk of all-cause mortality between the Digoxin group and the control group (HR1.04,95% CI 0.85~1.28,P=0.68). Conclusion:Use of Digoxin in clinical practice does not significantly increase the all-cause mortality.%目的：：荟萃分析地高辛对全因死亡率的影响。方法：收集Medline以及Cochrane数据文献,通过I2统计量进行异质性检验,用随机效应模型分析地高辛对全因死亡的风险,得到合并效应指标风险比及其95％可信区间。结果：最终纳入文献10篇,总样本量24865人,地高辛组的全因死亡率风险与对照组并无明显差异( HR1.04,95％CI 0.85~1.28,P＝0.68)。结论：临床应用中地高辛并未显著升高全因死亡率。