纳米羟基磷灰石与聚己内酯复合电纺纤维膜

摘要

用水热法合成的棒状纳米羟基磷灰石（nHA）,引发ε-己内酯（ε-CL）开环聚合得到nHA-PCL复合材料。用静电纺丝法分别制备了聚己内酯（PCL）、nHA/PCL共混材料和nHA-PCL复合材料的3种电纺纤维膜。通过FT-IR、DSC、SEM、TGA和拉伸试验机表征了样品的结构、热性能和力学性能。结果表明：nHA-PCL电纺膜的结晶性能优于nHA/PCL材料,且热稳定性和力学性能都优于其他两种膜,nHA-PCL电纺膜的完全分解温度为420°C,拉伸强度和断裂伸长率分别达到28.2MPa和55.6%。3种膜的纤维直径均小于500 nm,nHA-PCL电纺膜的纤维表面比较粗糙。在人体仿生液中诱导矿化4 d后,nHA-PCL电纺膜纤维表面出现磷灰石沉积,而纯PCL和共混nHA/PCL电纺膜的纤维表面沉积的磷灰石很少,nHA-PCL复合电纺膜具有较好的诱导成骨性能。%The rod-like nano-hydroxyapatite（nHA） which synthesized by hydrothermal route induced the ring-opening polymerization of ε-caprolactone and nHA-PCL composites were obtained.Polycaprolactone（PCL）,the mixed material（nHA/PCL） and nHA-PCL were used to prepare membranes respectively via electrospinning.The structure,mechanical properties and thermostability of the three electrospun membranes were characterized by FT-IR,DSC,SEM,TGA and tensile testing machine.The results of the FT-IR and DSC showed that PCL in nHA-PCL membrane had better crystalline ability than the other two membranes.The results of tests showed that nHA-PCL membrane had better mechanical properties and thermostability than other two membranes.The complete decomposition temperature of nHA-PCL membrane was 420 °C.The tensile strength and the breaking elongation of nHA-PCL membrane were 28.2 MPa and 55.6%,respectively.The SEM results showed that the fibers diameter of the three membranes were lower than 500 nm,but the fiber surface of nHA/PCL electrospun membrane became rough.After immersion in SBF for 4 d,there was much more calcium phosphate on the surface of nHA-PCL electrospun membrane comparing with PCL and nHA/PCL electrospun membranes.The bone-forming ability of nHA-PCL compound material was good.