磷酸胆碱表面改性涤纶材料及抗凝血性研究

摘要

Poly（ethylene terephthalate）（PET） film was exposed to oxygen plasma glow discharge to initiate graft polymerization of acrylic acid（AA） and introduce the carboxylic acid groups.Poly（2-methacryloyloxyethyl phosphorylcholine）（poly-MPC）were grafted onto PET surface by surface initiated atom transfer radical polymerization（ATRP）.The results of Fourier transform infrared spectroscopy with diffuse reflectance mode and X-ray photoelectron spectroscopy（XPS） revealed that poly-MPC was effectively grafted on the surface of PET.The hydrophilicity of MPC grafted PET（MPC-PET） was improved compared to control PET.There is less extent of in vitro platelet adhesion,activation and fibrinogen activation on the surfaces MPC-PET than that of the untreated PET.%采用氧等离子体预处理涤纶材料（聚对苯二甲酸乙二醇酯,PET）表面,并通过紫外辐照在其表面接枝聚合丙烯酸,以接枝聚丙烯酸链中的羧基为反应位点,通过原子转移自由基聚合在PET表面进一步固定磷酸胆碱聚合物。经漫反射红外光谱及X射线光电子能谱分析测试表明,涤纶薄膜表面成功地固定了磷酸胆碱聚合物。经磷酸胆碱聚合物改性的涤纶表面亲水性得到改善,体外抗凝血性评价表明,固定磷酸胆碱的PET表面能够有效地抑制纤维蛋白原分子的变性,降低血小板粘附和激活。