首发精神分裂症患者及其父母认知功能的听觉ERP评估

摘要

Objectives To expliore the possibility of cognitive disorder in patients with first-episode schizophrenia and in their parents? And to explore whether the event-related potentials (ERPs) is the genetic or the state markers in schizophrenia. Methods.- Sixty patients with schizophrenia were consecutively recruited from the patients in the Department of Psychiatry, Xuzhou Eastern People's Hospital whose symtoms met CCMD-3 criteria for schizophrenia. One hundred and twenty parents of the schizophrenic patients were consecutively chosen as the relative group. Sixty healthy subjects with out individual and familial history of mental illness were selected as the control group. ERPs in listening of all the subjects were examined respectively. All data were statistically analyzed by SPSS 13. 0. By chi-square test and a-nalysis of variance and covariance were used to contrast the ERPs of the three groups. Results: (1) The N2.N3 latency and P3 amplitude of ERPs in the patients group,relatives group and the control group were significantly different from each other (P<0. 01). (2) The patients group was significantly different from the control group in N2 latency (P<0. 01). The relatives group had no significant difference form the control group in the latency (P>0. 05). P3 amplitude of the patients and relatives groups were both significantly different form the control group (P<0. 01). The patients group had no difference form the relatives group in P3 amplitude (P>0. 05). Conclusion: The study supports the following points: (l)Both first-episode schizophrenia and their parents have defect of the functional of recognition. (2)P3 amplitude is possibly the genetic marker of the schizophrenia, and N2 latency in possibly the state marker of the schizophrenia.%目的:探讨首发精神分裂症患者及其父母是否存在认知功能障碍,以及事件相关电位( ERP)是精神分裂症的遗传素质标志还是状态性标志.方法:从2010年1～12月期间在徐州市东方人民医院住院的患者中选取符合CCMD-3精神分裂症诊断标准的首发患者60例,作为患者组；选取精神分裂症患者生物学意义上的父母,共120例作为亲属组；选取无精神疾病家族史的健康志愿者60名作为对照组.对3组进行听觉ERP检测,所得数据应用SPSS 13.0统计软件包处理分析,采用的主要统计学方法包括卡方检验、单因素方差分析和协方差分析.结果:①患者组、亲属组与对照组间ERP的N2、P3波的潜伏期和P3波的波幅比较,差异均有显著意义(均为P＜0,01)；②患者组的N2波的潜伏期长于对照组(P＜0.05),亲属组和对照组各波潜伏期比较,差异无统计学意义(均为P＞0.05)；③患者组和亲属组的P3波的波幅均明显低于对照组(均为P＜0.05),而患者组和亲属组P3波的波幅比较差异无统计学意义(P＞0.05).结论:首发精神分裂症患者及其父母可能存在一定程度的认知功能障碍;P3波波幅倾向于精神分裂症的遗传素质性标志,N2波潜伏期倾向于精神分裂症的状态性标志.