刺五加注射液治疗缺血性中风急性期随机对照试验的Meta分析

摘要

目的 系统评价刺五加注射液治疗缺血性中风急性期的疗效及安全性.方法 搜集刺五加注射液治疗缺血性中风急性期随机对照试验文献,筛选合格研究,应用Jadad评分法进行质量评价,运用异质性检验、Meta分析、漏斗图分析等方法统计相关数据.结果 16项研究符合纳入标准,Jadad评分显示所有研究得分均低于3分,属低质量文献.Meta分析结果显示,总有效率比较的合并相对危险度的99％ CI为1.18(1.11,1.26);手工计算需治疗患者例数的99％CI为6.67 (5,10);神经功能缺损评分比较的加权均数差的99％CI为-8.54(-10.47,-6.60).结论 Meta分析结果显示刺五加注射液可改善缺血性中风急性期患者的神经功能缺损程度状况,且安全性较好.%Objective:To evaluate the effect and the safety of acanthopanex injection on acute cerebral ischemic stroke. Methods;Studies of randomized controlled trails (RCTs) of acanthopanex injection on acute cerebral ischemic stroke were identified. The methodological quality of inclusive trails were assessed by Jadad scale. The data was analysed by the heterogeneity test,meta analysis and funnel plot analysis. Results: 16 RCTs whose Jadad score were lower than 3 were included. Meta-analysis indicated that the RR(99%CI) was 1.18(1.11,1.26) ,the NNT(99% CI) was 6.67 (5,10) and the WMD(99%CI) was -8.54(-10.47,-6.60). Conclusion:The meta analysis shows that the acanthopanex injection is effective and safety for acute cerebral ischemic stroke.