Ang-1、Ang-2、Tie-2及 VEGF 在尖锐湿疣组织中的表达

摘要

Objective:To detect the expression levels of angiopointin 1(Ang-1), angiopo intin 2(Ang-2), Tie-2 receptor and vascular endothelial growth factor (VEGF) in condyloma acuminata tissues.Methods:The expression levels of Ang-1, Ang-2, Tie-2 receptorand VEGF in 30 condy-loma acuminata tissues and 20 normal tissues were detected by immunohistochemical technique . Results:The positive rates of Ang-2 , Tie-2 receptor and VEGF in condyloma acuminata tissues were 100%、93.33% and 100%, significantly higher than 25.00%, 40.00% and 45.00% in normal tissues (χ²=32.14,16.93,18.07 respectively,P<0.01).The positive rates of Ang-1 in condyloma acuminata tissues was 33.33%, and there was no statistical significance compared with normal tissues (χ²=0.06 , P >0.05 ) .Conclusion:Ang/Tie-2 signal transduction system and VEGF may play an important role on growth and recurrence in condyloma acuminate .%目的：检测促血管生成素1（Ang-1）、促血管生成素2（Ang-2）、Tie-2受体及血管内皮生长因子（VEGF）在尖锐湿疣组织中的表达情况。方法：采用免疫组化法对30例尖锐湿疣患者皮损组织及20例正常对照组织中的Ang-1、Ang-2、Tie-2受体及VEGF进行检测。结果：Ang-2、Tie-2受体及VEGF在尖锐湿疣皮损组织中的阳性表达率分别为100％、93.33％和100％，明显高于正常组织的25.00％、40.00％和45.00％（礸2值分别为32.14、16.93、18.07，P值均＜0.01）；Ang-1在尖锐湿疣皮损组织中的阳性表达率为33.33％，与正常组织的30.00％比较，差异无统计学意义（礸2＝0.06，P＞0.05）。结论：Ang／Tie-2信号传导系统和VEGF在尖锐湿疣的发生中发挥重要作用。