复方浒苔多糖降血脂及抗脂质过氧化作用研究

摘要

目的：研究复方浒苔多糖（浒苔多糖、山楂提取物、荷叶提取物及茶多酚各25％配制而成）的降血脂及抗脂质过氧化作用。方法根据TC水平将42只大鼠随机分为空白组，高脂模型组，浒苔多糖组，复方浒苔多糖低、中、高剂量组。浒苔多糖组及复方浒苔多糖组分别给予浒苔多糖及不同剂量的复方浒苔多糖灌胃干预45 d，测定各组大鼠血清中的总胆固醇（ TC）、甘油三酯（ TG）、高密度脂蛋白胆固醇（ HDL－C）、低密度脂蛋白胆固醇（ LDL－C）的含量及超氧化物歧化酶（ SOD）和谷胱甘肽过氧化物酶（ GSH－Px）的活性。结果与高脂模型组比较，各剂量复方浒苔多糖的TC水平下降、GSH－Px活性提高；复方中、高剂量组的TG水平降低、SOD活性提高，复方高剂量组的HDL－C水平提高，复方低、中剂量组的LDL－C水平降低（ P＜0．05）。各剂量复方浒苔多糖的TC、TG、HDL-C水平、GSH－Px活性及高剂量复方浒苔多糖的SOD活性与单一浒苔多糖比较差异无显著性意义（ P＞0．05）。结论复方浒苔多糖与单一浒苔多糖具有相似的降血脂及抗脂质过氧化作用效果。%Objective To study the effect of compound Enteromorpha's polysaccharide on lowering blood lipid and anti-lipid peroxidation.Methods According to Tc content,42 rats were randomly divided into control, hyperlipemia model,En-teromorpha's polysaccharide,compound Enteromorpha's polysaccharide( low,middle and high doses) groups.Intervening in rats of Enteromorpha's polysaccharide group or compound Enteromorpha's polysaccharide groups through intragastric admin-istration of Enteromorpha's polysaccharide or all doses of compound Enteromorpha's polysaccharide for forty-five days, TC, TG, HDL-C,LDL-C content and SOD, GSH-Px activity in the serum were measured.Results In contrast to the hyper-lipemia model,TC content of all doses of compound Enteromorpha's polysaccharide decreased but GSH-Px activity im-proved;TG of middle and high doses decreased while SOD activity improved;HDL-C content of high dose improved and LDL-C content of low and middle doses decreased (P<0.05).TC,TG,HDL-C content and GSH-Px activity of all do-ses of compound Enteromorpha's polysaccharide in rats'serum had no statistical differences in contrast to single Enteromor-pha's polysaccharide, also was SOD activity of high dose (P>0.05).Conclusion Compound Enteromorpha's polysaccha-ride shows the similar effect of lowering blood lipid and anti-lipid peroxidation to single Enteromorpha's polysaccharide.