右美托咪定滴鼻给药用于小儿传染性软疣刮除术的镇静镇痛作用研究

摘要

目的 探讨右美托咪定滴鼻对小儿传染性软疣刮除术的镇静和镇痛效果.方法 60名4～6岁行传染性软疣刮除术的患儿被随机分为右美组(n =30,1.5 μg/kg右美托咪定滴鼻)和盐水组(n=30,0.015 mL/kg生理盐水滴鼻).记录患儿生命体征、刮除软疣个数、手术时间、行为评分、镇静疼痛评分、家长及医生满意度和达到出院标准时间.结果 右美组患儿的镇静、疼痛评分和行为评分均明显低于盐水组(分别为2±1和1±0,7±1和9±1,2±1和4±1),差异有统计学意义(P＜0.05);术毕时两组的患儿镇静程度以及出院时评分大致相同;右美组的患儿家属满意度以及医生满意度明显高于盐水组,差异有统计学意义.两组均无不良事件发生.结论 1.5 μg/kg右美托咪定滴鼻可以为小儿传染性软疣刮除术提供良好的镇静和手术配合.%Objective To evaluate the sedative and analgesia effects of intranasal dexmedetomidine in molluscum curettage among preschool children.Methods Totally 60 4-6 years old preschool children were recruited and randomly allocated into two groups:Dex group (n =30,patients were given 1.5 μg/kg inranasal dexmedetomidine) and Saline group (n =30,patients were given 0.015 mL/kg intranasal saline).Vital signs,surgery information,OAA/S score,action score,PADSS and satisfaction score of doctor and parents were recorded.Results The sedation score,NRS pain score and action score in Dex group were significantly lower than those in saline group (2 ± 1 vs.1 ± 0,7 ± 1 vs.9 ± 1 and 2 ± 1 vs.4 ± 1 respectively,P ＜ 0.05).The satisfaction scores of both doctor and parents in Dex group were significantly higher than those in saline group.No adverse events happened in both groups.Conclusion Intranasal dexmedetomidine might provide satisfactory sedation and analgesia during molluscum curettage among preschool children without adverse complications.