高血压病患者颈动脉管径增大指数、单点脉搏波传导速度与脉压差的关系

摘要

目的 利用血管回声跟踪技术(ET)测量高血压病患者的颈动脉弹性功能,探讨管径增大指数(AI)、单点脉搏波传导速度(PWVβ)与动脉弹性功能的关系.方法 高血压病患者90例,均分为三组:A组肱动脉脉压差＜60 mm Hg,B组脉压差为60～80 mm Hg,C组脉压差≥80 mm Hg.测量患者颈动脉ET参数:硬化指数(β)、压力-应变弹性系数(Ep)、顺应性(AC)、AI、PWVβ及肱动脉脉压差,比较不同脉压差组间颈动脉弹性功能参数的差异.结果 A、B、C三组间收缩压依次增高,B、C组收缩期颈动脉内径(Ds)、舒张期颈动脉内径(Dd)较A组增高,差异均有统计学意义(P<0.05).B组和C组β、Ep、AC、AI较A组增高,差异有统计学意义(P<0.05).AI与年龄、IMT、脉压差呈正相关,与Ds-Dd呈负相关;PWVβ与年龄、收缩压、脉压差、Dd 呈正相关,与Ds-Dd呈负相关.结论 AI、PWVβ随脉压差增大而增大,参数异常早于脉压差增大,二者结合能较敏感地早期反应动脉弹性功能.%Objective To measure carotid artery elasticity function in patients with hypertension by ET technology, and to analyze the relationship between Al, PWVβ and carotid artery elasticity function. Methods Ninety patients with hypertension were divided into three groups: group A was pulse pressure (PP) ＜ 60 mm Hg,group B was 60 mm Hg≤ PP ＜ 80 mm Hg and group C was PP≥80 mm Hg. ET parameters of carotid artery were measured, including β, Ep, AC, Al, PWVβ and PP. The carotid artery elasticity function parameters between different PP groups were compared. Results Systolic pressure in A, B, C groups was increased, Ds and Dd in B, C groups were higher than those in A group, there was significant difference (P ＜0.05). β, Ep、AC and Al in B, C groups were higher than those in A group, there was significant difference (P ＜0.05). There was positive correlation between Al and age, IMT, PP, while there was negative correlation between Al and Ds - Dd. PWVβ was positively correlated with age, systolic pressure, PP and Dd, while negatively correlated with Ds- Dd. Conclus ion Al and PWVβ increase with PP, the abnormality of parameter value is earlier than increase of PP. Combination of AI and PWVβ is more sensitive than PP in early reflecting the artery elasticity function.