Objective To Compare the preventive effect of glycyrrhizin diamine enteric-coated capsules on ATDH. Methods 80 patients, who were confirmed tuberculosis, were randomly divided into the test group,control group and blank group. Glyeyrrhizin diamine enteric-coated capsules, bicyclols and without drugs were respectively applied, the occurrence of ATDH were observed and related indicators were detected during 180 days in the standard anti-TB treatment. Results ATDH incidence in the test group was 25% , and it appeared at 101. 20 ±23.70 day;ATDH incidence in the control group was 34. 3% ,and it appeared at 34.42 ±6.072 day. And the incidence in the blank group was 44% .and it appeared at 50. 91 ± 12.03 day. The test group was significantly delayed(P =0. 007) ,and ALT values were lower( P = 0.046). Multiple comparisons in eosinophil ratio of the three groups, showed that the test group was significantly lower than the control group and blank group (P =0. 024). Conclusions Glyeyrrhizin diamine enteric-coated capsules may delay the occurrence of ATDH,reduce their severity,and alleviate allergic inflammation in tuberculosis.%目的 比较研究甘草酸二胺肠溶胶囊对抗结核药物性肝损( ATDH).方法 将80例确诊初发肺结核患者随机分为实验组、对照组和空白组,分别施用甘草酸二胺肠溶胶囊、双环醇片和不用保肝药,观察180天标准抗结核治疗过程中的ATDH发生情况及检测相关指标.结果 实验组ATDH发生率25%,出现ATDH时间为101.20±23.70天;对照组ATDH发生率34.3%,出现ATDH时间为34.42±6.072天;空白组发生率44%,出现ATDH时间50.91±12.03天.实验组ATDH出现时间显著延后(P =0.007).结论 甘草酸二胺肠溶胶囊可延后ATDH的发生时间,降低其严重程度,并缓解抗结核期间炎性过敏反应.
展开▼