目的 探讨ⅢA期N2非小细胞肺癌术(NSCLC)术后放疗疗效及其预后影响因素.方法收集确诊的195例ⅢA期N2 NSCLC术后放疗患者资料,以5年生存情况作为预后指标.结果 ⅢA期N2 NSCLC1年、3年、5年生存率分别为58.5%、29.7%、19.0%;多因素COX回归结果显示,影响N2期预后的独立因素包括肿瘤体积(OR=2.840)、T分级(OR=1.923)、N2转移组数(OR=2.672)为危险因素,而N2包膜完整性(OR=0.316)和放疗剂量(OR=0.270)为保护因素.结论 ⅢA期N2 NSCLC患者术后5年生存率较低,预后较差;肿瘤体积越大、T分级越高、N2淋巴结转移组数越多、N2包膜不完整、术后放疗剂量越低,是N2 NSCLC期术后预后的独立危险因素.%Objective To explore the curative effect and prognostic factors of radiotherapy in the treatment of patients with N2 non-small cell lung cancer (NSCLC ) at ?A period. Methods The clinical data of 195 patients with N2 NSCLC were retrospectively analyzed , and 5-year survival was considered as the prognostic index. Results The survival rates of 1 year, 3 years and 5 years survival rates were respectively 58. 5% , 29. 7% and 19. 0% . The results of multiple factors COX regression showed that the independent risk factors included gross tumor volume ( OR = 2. 840 ), T grades ( OR=1. 923 ), and N2 metastasis groups ( OR = 2. 672 ). N2 amicula integrity ( OR = 0. 316 ) and radiotherapy dose ( OR = 0. 270 ) were protective factors. Conclusion The 5-year survival rate is a little lower in patients with N2 NSCLC with poor prognosis. The independent risk factors include gross tumor volume, high T-grade, N2 metastasis groups, N2 amicula imperfect and low radiation dose.
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