Objective To analyze the therapeutic effect of combined interventional therapy in acute pulmo-nary embolism (APE)and low dose intravenous thrombolytic therapy in the treatment of acute pulmonary infarction. Methods 100 patients with APE were randomly divided into two groups,50 cases in each group.The control group received interventional therapy combined with conventional intravenous thrombolytic therapy,and the observation group received interventional therapy combined with low dose intravenous thrombolytic therapy for long time.The clinical efficacy and safety were compared between the two groups.Results There was no significant difference in survival rate between the two groups (P >0.05).The levels of PO2 and D-dimer in the two groups were not signifi-cantly different (P >0.05).10h after treatment,the level of PO2 increased significantly,and the level of D-dimer decreased significantly in the two groups,while there was no significant difference between the two groups (P <0.05).The incidence of bleeding complications in the observation group was significantly lower than that in the con-trol group (P <0.05).Conclusion Interventional therapy and low dose intravenous thrombolytic therapy can re-duce the incidence of side effects in patients without decrease in treatment effect.%目的：分析急性肺梗塞（APE）治疗中联合介入治疗及低剂量长时间经静脉溶栓治疗的应用效果。方法将100例 APE 患者作为观察对象，并以随机数字表法将患者随机分为两组，每组50例。对照组接受介入治疗联合常规静脉溶栓治疗，观察组接受介入治疗联合低剂量长时间经静脉溶栓治疗。对比两组临床治疗效果及治疗安全性。结果两组间生存率及溶栓治疗总有效率比较未见统计学差异（P ＞0.05）。两组治疗前 PaO2及 D-二聚体水平比较未见统计学差异（P ＞0.05），在接受治疗10 h 后两组 PaO2明显升高， D-二聚体水平明显下降，而两组间比较未见统计学差异（P ＞0.05）。观察组治疗期间出血并发症发生率明显低于对照组（P ＜0.05）。结论联合介入治疗及低剂量长时间经静脉溶栓治疗，可在不降低治疗效果的同时，降低患者的副作用发生率。
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