目的 探索新发活动性肺结核彻底治愈及减少复发的有效措施.方法 对门诊2001-2010年接受复查和随访的初治涂阳703例和涂阴896例肺结核病人随访结果进行统计,随访观察5年期间的复发情况.结果 初治涂阳肺结核实验组285人,5年间复发5人,复发率1.75%,其中涂阳1人,涂阳复发率0.35%;对照组418人, 5年间复发38人,复发率9.09%,其中涂阳22人,涂阳复发率5.26%.初治涂阴肺结核实验组386人,复发5人,复发率1.3%,未检出涂阳病例;对照组510人,复发51人,复发率10%,其中检出涂阳病例4人,涂阳复发率0.78%.初治涂阳和涂阴肺结核实验组的复发率与涂阳复发率明显低于对照组,对比差异具有统计学意义(P<0.05).结论 活动性肺结核初治涂阳和初治涂阴患者经短程督导化疗治愈和疗程期满治愈后,继续使用异烟肼加利福喷丁加微卡和健脾润肺丸巩固治疗2-3个月后,具有良好的治愈效果,复发率明显降低.%Objective To explore the effective measures for the cure and recurrence control of new active pulmonary tuberculosis.Methods From 2001 to 2010, 703 cases of smear positive and 896 cases of smear negative pulmonary tuberculosis were followed up for 5 years, and the results were analyzed.Results There were 5 recurrence cases out of 285 cases in the initial treated smear positive pulmonary tuberculosis group during the five years (1.75%), including 1 smear positive case (0.35%).There were 38 recurrence cases out of 418 cases in the control group during the 5-year follow-up (9.09%), including 22 smear positive cases (5.26%).There were 5 recurrence cases out of 386 cases in the smear negative pulmonary tuberculosis group (1.3%).There were 51 recurrence cases out of 510 cases in the control group (10%), including 4 smear positive cases (0.78%).The recurrence was obviously lower in the smear positive and negative pulmonary tuberculosis experiment group than in the control group (P<0.05).Conclusion initial treatment smear positive initial treatment smear negative patients cured by dots and course of the expiration of the cure, the continued use of isoniazid, rifapentine, microcalory and Jianpi Runfei pill for 2-3 months has the advantages of good curative effect and low recurrence in treatment of active pulmonary tuberculosis patients with initial treated smear positive and negative.
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