大剂量氨溴索在肿瘤术后继发肺炎患者中的应用

摘要

目的 探讨肿瘤术后患者行大剂量氨溴索治疗术后肺炎的临床疗效. 方法 选取100例各类恶性肿瘤术后继发肺炎患者作为本次研究观察对象,随机分为两组,每组患者各50例,两组患者均给予常规基础治疗,对照组予以常规剂量氨溴索治疗,观察组采用大剂量氨溴索治疗,比较两组患者治疗前后CRP、TNF-α、WBC水平、ANC水平变化,比较两组患者抗生素使用时间、影像学消失时间及住院时间.结果 两组患者治疗后,CRP、TNF-α、WBC、ANC水平均显著低于治疗前(P<0.05),其中在治疗后第3天、第5天、第7天,观察组患者下降水平更明显(P<0.05);经过不同方式治疗后,观察组较对照组患者在抗生素使用时间上更少、影像学消失时间更快、住院时间更短(P<0.05).结论 大剂量氨溴索用于肿瘤相关性肺炎患者的治疗,能提高抗菌药物浓度,提高疗效.%Objective To investigate the clinical efficacy of high dose ambroxol in treatment of postoperative pneumonia in cancer patients after surgery.Methods 100 patients with various types of malignant tumor secondary to pneumonia was randomly divided into two groups.All patients were given conventional basic therapy, the control group received the conventional dose ambroxol cable therapy, and the treatment group was given high-dose ambroxol.The levels of CRP, TNF-α, WBC, and ANC were compared, and their antibiotic usage time, radiographic disappearance time and hospital stay were also recorded.Results After treatment, CRP, TNF-α, WBC and ANC were significantly lower than before treatment (P<0.05), which was more obvious in the observation group at the third, fifth, and seventh days after treatment (P<0.05).The time of antibiotic use, imaging disappear and hospital stay was shorter in the treatment group than in the control group (P<0.05).Conclusion Large dose of ambroxol hydrochloride can improve the concentration of antibiotics and the curative effect in treatment of patients with tumor associated pneumonia.