Objective: To explore efficacy and safety of clonazepam intravenous injection in treatment ol acute excitement of psychotic patients. Method:The psychotic patients with acute excitement were randomly divided into the study group (n = 110) and the control group (n = 108). The study group received 2 ～4 mg/d clonazepam intravenous injection treatment while the control groups received l0 ～ 21 mg/d haloperidol intravenous injection treatment. The curative effects were assessed after 6 hours. Results: After 6 hours, 78 in the study group and 58 in the control group was quiet (P ＜0.01 ) and the average time when patients took to calm down were ( 8.99 ± 5.62 ) and ( 26.78 ± 16.38 ) minutes respectively ( P ＜ 0.01 ); 26 in the study group and 44 in the control group were given restraint and the average restraint time was (56.57 4±56.97 ) and (87.52 4± 59.67 ) minutes respectively ( P ＜0.01 ) ;83 in the study group and 60 in the control group cooperated with the treatment;The study group showed significant lower (modified overt aggression scale) score than the control groups ( P ＜ 0.01 ); There were no significant differences on side effects between the two groups ( P ＞ 0.05 ). Conelusion:Clonazepam intravenous injection is effective and safe in treatment of the acute excitement of psychotic patients.%目的:观察静脉注射氯硝西伴对兴奋状态精神疾病患者的疗效和安全性.方法:将患者随机分为研究组(n=110)和对照组(n=108),研究组静脉注射氯硝西泮2-4 mg,对照组肌内注射氟哌啶醇10-20 mg.观察给药后6h患者安静下来的例数及所需时间、需要防护例数及防护时间、合作例数和修订版外显攻击行为(MOAS)评分.结果:6h后研究组安静下来78例,对照组58例(P<0.01);研究组安静下来需(8.99土5.62)min,对照组(26.78±16.38)min(P<0.01).研究组需防护26例,对照组44例(P<0.01);研究组防护时间(56.57±56.97)min,对照组(87.52±59.67)min(P<0.01).研究组合作83例,对照组60例(P<0.01).研究组WAS评分较对照组显著降低(P<0.01).氯硝西泮不良反应多为轻度或中度,无须特殊处理.结论:静脉注射氯硝西洋能快速控制精神疾病患者的兴奋状态,提高护理合作率,降低防护率,缩短防护时间,家属容易接受,安全性大,有推广价值.
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