酒精所致震颤谵妄患者血液相关指标的对照研究

摘要

Objective: To investigate the blood related indexes in the patients with delirium tremens dueto alcohol dependence and explore the high risk factors for delirium tremens. Method; 142 male inpatients with alcohol dependence were divided into two groups ( delirium tremens and non delirium tremens) in terms of delirium tremens occurrence. The blood related indexes were measured and compared between the two groups. Results; Compared non delirium tremens group, delirium tremens group showed higher levels on AST (aspartate aminotransferase) [ (183.53 ± 174. 55 ) U/L vs. (95. 83 ± 118. 38 ) U/L] , GGT ( glutamate transaminase) [(647.26 ±618. 27) U/L vs. (250.48 ±313. 91) U/L] ,CK(creatine kinase) [ (738. 85 ± 1023. 72)U/L vs. (330.59 ±433.42)U/L] and Ca [(2.34 ±0.91) mmol/1 vs. (2.22 ±0. 14)mmol/l] ,and lower levels in HGB (hemoglobin) [ (126.00 ± 17.77)g/l vs. (135.38 ± 17.85)g/l] ,RBC(red blood cell) [ (3.55 ±0.64) x 1012/L vs. (3.93 ±0.60) ×10'2/L],PLT (platelet count) [ (86.41 ±31.56) x 109/L vs. ( 173.78 ±79.44) x 109/L],K[(3.45±0.75)mmol/L vs. (3.88 ±0.55)mmol/L] and Cl [(100.94 ±5.02)mmol/L vs (104.46 ± 6.64)mmol/L]. The above index differences between the two groups were statistically significant (P<0.05 or P < 0.01). Logistic regression analysis indicated that thrombocytopenia and low serum potassium were risk factors fro delirium tremens. Conclusion;The blood related indexes in patients with alcohol dependence to some degree can predict delirium tremens onset.%目的:对酒依赖患者进行血液相关指标的观察与分析,探讨慢性酒精中毒患者发生震颤谵妄(delirium tremens,DT)的高危因素. 方法:对近4年142例首次住院的男性酒依赖住院患者按照是否出现DT分组进行血液相关指标比较. 结果:出现震颤谵妄(DT)的17例酒依赖患者与非震颤谵妄组相比,在谷草转氨酶[(183.53±174.55) U/L;(95.83±118.38) U/L]、谷氨酸转氨酶[(647.26±618.27)U/L; (250.48±313.91) U/L]、及肌酸激酶[(738.85±1023.72)U/L;(330.59±433.42) U/L]及钙[(2.34±0.91) mmol/l;(2.22±0.14) mmol/l]显著升高；而血红蛋白[(126.00±17.77) g/l;(135.38±17.85) g/l]、红细胞[(3.55±0.64)×1012/L; (3.93±0.60)×1012/L]、血小板[(86.41±31.56)×109/L;(173.78±79.44)×109/L]、钾[(3.45 ±0.75)mmol/l;(3.88±0.55) mmol/l]及氯[(100.94±5.02) mmol/l；(104.46±6.64) mmol/l]则显著降低,差异均有统计学意义(P＜0.05或P＜0.01).Logistic回归分析显示,戒酒患者发生DT的危险因素有:血小板减少和血钾降低. 结论:酒依赖患者血液相关指标对DT预测具有一定参考意义.