缺陷型及非缺陷型精神分裂症首次发病未服药患者失匹配负波的对照研究

摘要

Objective:To explore the characteristics of mismatched negativity (MMN) and correlation with clinical status in first-episode deficit and non-deficit forms schizophrenia patients who not received treatment.Method:According to the assessed by deficit form schizophrenia diagnosis scale (SDS),100 first-episode schizophrenia patients who not received treatment were classified as deficit form schizophrenia (DS) group (45 cases) and non-deficit form schizophrenia (NDS) group (55 cases).MMN of the patients was measured by brain evoked potentiometer,and the results were compared with 50 normal controls (control group).The relationships between MMN changes and age,course of disease,condition and functioning status of the patients were analyzed.Results:Compared to control group,MMN latency and amplitude in DS and NDS groups were significantly delayed and decreased (F =21.72,F =5.95 ; all P =0.00) ; but there were no significantly differences of MMN latency and amplitude between groups of DS and NDS(all P ＞ 0.05).Non correlation had been found between variables of MMN latency and amplitude with age of onset,course of disease,the scores of positive and negative syndrome scale (PANSS,including total score,positive symptoms score,negative symptoms score and general psychopathology score),score of global assessment functioning(GAF) in groups of DS and NDS(all P ＞ 0.05).Conclusion:Abnormalities of MMN are existed in patients with deficit type and nondeficit type schizophrenia.It maybe the trait marker of patients with schizophrenia.%目的:探讨缺陷型与非缺陷型精神分裂症首次发病未服药患者失匹配负波(MMN)的特征及与临床状态的相关性. 方法:根据缺陷型精神分裂症诊断量表评分将100例首发精神分裂症患者分为缺陷型(缺陷组,45例)和非缺陷型(非缺陷组,55例);采用脑诱发电位仪检测MMN,并与50名正常对照者(对照组)比较;分析患者MMN改变与其发病年龄、病程、病情及功能的关系. 结果:与对照组比较,缺陷组与非缺陷组MMN潜伏期明显延长(F=21.72,P =0.00),波幅明显降低(F=5.95,P=0.00);缺陷组与非缺陷组间MMN潜伏期及波幅差异无统计学意义(P均＞0.05).患者的MMN潜伏期及波幅与的其发病年龄、病程、阳性和阴性症状量表(PANSS)评分(包括总分、阳性症状分、阴性症状分、一般精神病理分)及大体功能评定量表(GAF)评分无显著相关性(P均＞0.05). 结论:缺陷型和非缺陷型首发精神分裂症患者均存在MMN异常;其可能是精神分裂症患者的素质性标记.