Objective: To evaluate the efficacy and safety of escitalopram for depressive patients. Method: Forty-two depressive patients were randomized into escitalopram group ( n = 20 ) and citalopram group (n =22) for a 6 weeks double-blind study. 17 items HAMD and treatment emergent symptoms scale were used to assess the effectiveness and safety before treatment and by the end of 1,2,4,and 6 weeks. Results:After 6 weeks of treatment, the HAMD scores decreased from (23.06 ±2.22)and(22.78 ±2.03)to(7.76 ±2.98) and (7.90 ±3. 11) in the escitalopram group and the citalopram group respectively, the effective rate was 80.0% and 77. 3% ,and the curative rate was 50. 0% and 45. 5%. There was no significant difference in the effective and curative rate between the 2 groups (χ2 =0.046,P = 0. 830; χ2 =1.828,P=0.176). No significant difference was found in main side effects between the 2 groups (P>0.05). Conclusion: Escitalopram and citalopram are similarly effective and safe in the treatment of depression, but escitalopram has earlier response.%目的:观察艾司西酞普兰与西酞普兰治疗抑郁症的疗效及安全性. 方法:将42例抑郁症患者随机分为艾司西酞普兰组20例(艾司西酞普兰治疗)和西酞普兰组22例(西酞普兰治疗),疗程6周.于治疗前及治疗1、2、4和6周分别采用17项汉密尔顿抑郁量表(HAMD)和治疗中出现的症状量表(TESS)评定疗效和不良反应. 结果治疗6周,艾司西酞普兰组和西酞普兰组的HAMD总分分别从治疗前(23.06±2.22)分和(22.78 ±2.03)分降至(7.76 ±2.98)分和(7.90±3.11)分；两组有效率分别为80.0％和77.3％(x2=0.046,P=0.830),痊愈率分别为50.0％和45.5％(x2=1.828,P=0.176).两组间不良反应差异无统计学意义(P＞0.05). 结论:艾司西酞普兰与西酞普兰抗抑郁疗效相同,但艾司西酞普兰起效更快.
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