Objective To investigate the efficacy and safety of autologous serum eye drops in the treatment of fila-mentary keratitis after excimer laser corneal refractive surgery.Methods 52 patients in our hospital treated with filamenta-ry keratitis between August 2014 and August 2016 were selected and randomly divided into two groups.26 cases in the con-trol group(50 eyes)were treated with conventional therapy;26 cases in the experimental group(50 eyes)were treated with autologous serum eye drops.The number of corneal filament and the changes of symptoms,signs and cure time before and after treatment in two groups were observed,and the results were analyzed in SPSS 22.0.Results All patients had significantly lower corneal silk volume and the less symptoms and signs after treatment(P <0.05).Compared with the control group,the number of corneal wound and the score of symptoms and signs in the experimental group were lower(P<0.05),and the cure time(12.77 ±2.01 days)and recurrence rate(4.00%), adverse reaction rate were also lower than those in the control group(12.77 ±2.01 days,18.00%;P <0.05).Clinical efficacy of the experimental group was better than that of the control group(Z=-2.339,P <0.05).Total effective rate(92%)was higher than that of the con-trol group(72%)but the difference was not statistically significant(χ2=2.439,P >0.05).The incidence of adverse re-actions in the experimental group was significantly lower than that in the control group(χ2=7.200,P <0.05).Conclu-sions Autologous serum eye drops can effectively reduce the incidence of filiform keratitis,coiling quantity,and healing time in patients received excimer laser corneal refractive surgery.It has good clinical efficacy and safety,and is worthy of clinical application and promotion.%目的 探讨自体血清滴眼液治疗准分子激光角膜屈光手术后丝状角膜炎的临床疗效及安全性.方法 选取2014年8月至2016年8月于本院眼科以丝状角膜炎为诊断进行治疗的患者52例,随机分为两组:对照组26例(50只眼),予临床常规治疗;实验组26例(50只眼),予自体血清滴眼液治疗.观察两组患者治疗前后角膜卷丝数量和症状、体征评分和治愈时间水平变化及临床疗效和安全性,其结果应用统计学软件SPSS 22.0进行数据分析.结果 与治疗前相比,治疗后两组患者的角膜卷丝数量和症状、体征评分水平均较治疗前明显减低(P <0.05);与对照组比较,实验组患者治疗后角膜卷丝数量和症状、体征评分水平水平低于对照组(P <0.05);实验组患者治愈时间(12.77 ±2.01)d及复发率(4.00%)明显低于对照组患者(12.77 ±2.01)d/18.00%,P <0.05;实验组临床疗效明显优于对照组(Z =-2.339,P <0.05),总有效率(92.00%)高于对照组(72.00%),组间差异不具有统计学意义(2=2.439,P >0.05);两组不良反应发生情况对比差异显著(2=10.000,P <0.05),实验组不良反应发生率显著低于对照组(2=7.200,P <0.05).结论 自体血清滴眼液可有效减少准分子激光角膜屈光手术术后丝状角膜炎患者角膜卷丝数量、缩短治愈时间,具有较好的临床疗效和安全性,值得临床应用和推广.
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