Objectives To evaluate the efficacy and safety of self-designed computer-assisted cognitive impairment rehabilitation system ( CCRS) combined with donepezil hydrochloride in the treatment of patients with traumatic brain injury( TBI) . Methods 270 patients with TBI screened by computer-assisted cognitive assessment system ( CCAS) were divided into mild, moderate and server cognitive impairment ,each group has 90 patients, and divided into three subgroups by the order of treatment time, each subgroup has 30 patients. The control group was treated with convention of neurosurgery, group A was treated with donepezil and group B was treated with computer-assisted cognitive impairment rehabilitation system combined with donepezil hydrochloride. All patients were treated for 1 month. The efficacy was measured by CCAS. Results Group A and Group B both showed significant post-treatment results. There were significant difference between group B and group A. Conclusions CCRS combined with donepezil hydrochloride is more effective and safe in the treatment of TBI cognitive impairment. Furthermore , CCRS has more convenient than traditional cognitive rehabilitation on visual and auditory sense. It will be a tendency to treat cognitive impairment by CCRS.%目的 自行研发计算机辅助认知障碍康复训练系统(CCRS)软件,并探讨CCRS 联合盐酸多奈哌齐治疗创伤性颅脑损伤认知障碍的疗效与安全性.方法 根据目前国内外认知研究结果研发出适用于TBI 认知训练的软件,用自行研制的计算机辅助认知评定系统(CCAS)筛选出270 例存在认知障碍的TBI 患者,其中轻、中、重度认知障碍患者各90 例,并按入院时间先后顺序分别分为三个亚组,每组30 例.对照组按神经外科常规治疗,在神经外科常规治疗的基础上加用盐酸多奈哌齐和CCRS 联合盐酸多奈哌齐分别作为治疗组,连续治疗一个月,一个月后再次使用CCAS 评定其疗效.结果 盐酸多奈哌齐和CCRS 联合盐酸多奈哌齐治疗后患者认知功能较前有明显提高;CCRS 联合盐酸多奈哌齐较单独使用盐酸多奈哌齐治疗后患者认知功能有明显提高.结论 CCRS 联合盐酸多奈哌齐对TBI 认知障碍患者具有更好的疗效,不良反应轻微,而且CCRS 具有比传统认知训练在视、听效果及资料的统计方面更强的优势.
展开▼
