Creutzfeldt－Jakob病的MRI动态改变（附1例报告）

摘要

目的：探讨Creutzfeldt－Jakob病（ CJD）的MRI动态改变。方法回顾性分析1例CJD患者的临床资料。结果本例患者以进行性痴呆为特征，伴有共济失调、肌阵挛，发病3个月后达晚期。 DWI示早期双侧额、颞、顶、枕叶皮质、海马异常稍高信号，颞叶明显；随疾病进展脑皮质及海马异常信号变强，范围变大；晚期随着脑萎缩出现，脑皮质及海马异常高信号逐渐消失。患者因反复肺部感染死亡。结论散发型CJD患者DWI表现为早期病灶高信号，最常见于大脑皮质。%Objective To investigate the dynamic change of MRI in Creutzfeldt-Jakob disease ( CJD ) . Methods The clinical data of 1 sporadic CJD patient were analyzed retrospectively.Results The clinical features were progressive dementia, accompanied with ataxia and myoclonus in this case, and she reached terminal stage at 3 months after the onset of the disease.DWI showed the mildly hyperintensities in both side of cortex of frontal, temporal, parietal, occipital lobe and hippocampus, and especially of temporal lobe. With the progressive exacerbation of disease, the hyperintensities in cortex and hippocampus became higher and gradually distributed wider region.Late as brain atrophy, DWI displayed abnormally hyperintensities gradually decreased in both side cortexes of cerebra and hippocampus.The patient was died of pulmonary infection.Conclusion The DWI of sporadic CJD shows hyperintensities in the early stage, mostly in cerebral cortex.