Objective To observe the influence of sevoflurane used in extracorporeal circulation (CPB) on the concentration of blood glucose. Methods A total of 100 patients with double valves or coronary artery bypass grafting by CPB were divided into 2 groups. The sevoflurane group (observation group) received sevoflurane at the beginning of CPB without intravenous anesthetics. The intravenous anesthetics group (the control group) was added fentanyl, vecuronium, midazolam during shunting period without inhalation anesthetics. The blood samples were collected in these following time points: before the CPB ( T1 ) , clamped the aortic ( T2) , the beginning of rewarming ( T3) , and the end of CPB ( T4 ) and 24 h after operation ( T5 ) . The concentration of the blood glucose was measured. Results The blood glucose concentration showed no significant difference in the same time between two groups {P >0. 05). The blood glucose concentration showed no significant difference between T3 and T4 in each group (P >0.05). There was significant different among other times in each group (P<0. 05). Conclusion There is no significant influence on blood glucose between sevoflurane used in CPB and anesthetized in venous.%目的 观察体外循环中持续性应用七氟烷对血糖的影响.方法 将体外循环(CPB)下行心脏双瓣或冠状动脉搭桥手术患者100例随机均分为2组:七氟烷组(观察组)所有患者CPB开始时即持续吹入七氟烷,至停机时不再给予静脉麻醉药；静脉麻醉组(对照组)转流期间静脉追加芬太尼、维库溴胺、咪达唑仑,CPB期间不予吸入麻醉.分别于CPB开始时(T1)、阻升主(T2)、复温(T3)、停机(T4)及手术后第24小时(T5)抽取血样检测血糖.结果 2组间比较各时间点血糖浓度均无显著性差异(P＞0.05)；2组内T3、T4这2个时间点比较,血糖浓度无显著差异(P＞0.05),其余各时间点比较,血糖浓度差异均有统计学意义(P＜0.05).结论 CPB中使用七氟烷与静脉麻醉对血糖的影响无显著性差异.
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