达英-35联合二甲双胍对非胰岛素抵抗型多囊卵巢综合征患者的疗效观察

摘要

Objective To compare the clinical efficacy between diane-35 combined with metformin and single application of diane - 35 in non - insulin - resistant patients with polycystic o-vary syndrome (PCOS). Methods A total of 126 non - insulin - resistance patients with PCOS were selected and randomly divided into diane - 35 group ( n = 63) and diane - 35 combined with metformin group (n - 63). The changes of body mass index (BMI),fasting insulin (FINS),luteinizing hormone (LH),follicle - stimulating hormone (FSH) and testosterone (T) in the two groups were observed after three courses of treatment. Results After treatment,the levels of BMI,FINS,LH and FSH were slightly lower in diane - 35 group,but no significant improvement was observed. T level was significantly reduced. After treatment,the levels of BMI,FINS,LH and FSH in the diane - 35 combined with metformin group were significantly decreased. Conclusion Diane - 35 combined with metformin significantly improves BMI and androgen levels in non - insulin- resistant patients with PCOS with proved efficacy.%目的 对比观察达英-35、二甲双胍2者联用与达英35单用对多囊卵巢综合征(PCOS)非胰岛素抵抗型患者的疗效.方法 选取PCOS非胰岛素抵抗型患者126例,随机分为2组,各63例,分别应用达英- 35及达英- 35、二甲双胍联用治疗,观察2组治疗3个疗程后体重指数(BMI)、空腹胰岛素(FINS)、黄体生成素(LH)、促卵泡素(FSH)及睾酮(T)的改善情况.结果 单用达英- 35组治疗后BMI、FINS、LH、FSII水平均稍有降低,但较治疗前无明显改善,T水平与治疗前比较有显著降低.联合用药组治疗后BMI、FINS、LH、FSH及T水平较治疗前均下降明显.结论 达英35、二甲双胍能明显改善非胰岛素抵抗型PCOS体重指数及雄激素水平,是一种有效治疗方法.