目的：比较三种不同杀菌方法治疗老年幽门螺杆菌（Hp）感染患者的疗效。方法将患者随机分为 A 组68例， B 组70例和 C 组70例，分别给予序贯疗法、新三联疗法和标准三联疗法治疗。3组疗程均为10 d，停药4周后13C 尿素呼气试验评估 Hp 根除率。结果 A、B、C 组的 Hp 根除率分别为85．29％、80．00％和61．43％，A 组 Hp 根除率显著高于 B、C 组，且与 C 组比较差异有统计学意义（P ＜0．01）；B、C 组 Hp 根除率比较差异亦有统计学意义（P ＜0．01）；3组不良反应发生率比较差异无统计学意义（P ＞0．05）。结论10 d 序贯疗法、新三联及标准三联均能有效根除 Hp 感染，且无明显不良反应，但10 d序贯疗法效果更为显著。%Objective To compare the efficacy of three different disinfection methods in the treatment of elderly patients with helicobacter pylori infection (Hp).Methods Elderly pa-tients were randomly divided into group A (n =68),group B(n =70)and group C (n =70),and three groups were treated with sequential therapy,the new triple therapy and standard triple thera-py respectively.A course of treatment was 10 days in all the groups,and 4 weeks after drug with-drawal,13C urea breath test was used to assess the eradication rate of Hp.Results The eradica-tion rates in the group A,group B and group C were 85.29%,80.00%and 61.43% respectively. The eradication rates in group A and group B were significantly higher than that in the group C (P<0.01),but there was no significant difference between group A and group B.There were no sig-nificant differences of incidence rates of adverse reactions among three groups (P >0.05).Conclu-sion 10 days sequential therapy,the new triple therapy and standard triple therapy are proved to be effective in treating and eradicating Hp and there is no obvious adverse reactions.Among three methods,efficacy of 10 days sequential therapy is more significant.
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