鼻式间歇正压通气联合咖啡因用于防治早期早产儿拔管失败的临床研究

摘要

目的 研究鼻式间歇正压通气联合咖啡因防治早期早产儿拔管失败的临床效果.方法 选取50例胎龄≤32周的新生儿呼吸窘迫综合征(NRDS)早产儿,随机分为对照组(经鼻持续气道正压通气+氨茶碱治疗)和观察组(鼻式间歇正压通气联合咖啡因治疗),比较2组临床效果.结果 观察组并发症发生率为16％,显著低于对照组的32％(P＜0.05);2组患者治疗后1h血气指标无显著差异,观察组治疗后12h血气指标显著优于对照组(P＜0.05).结论 鼻式间歇正压通气联合咖啡因可显著改善早期拔管失败早产儿血气指标,降低并发症发生率.%Objective To explore the clinical effect of nasal intermittent positive pressure ventilation combined with caffeine on the prevention and treatment of premature infants with extubation failure.Methods Totally 50 infants with neonatal respiratory distress syndrome (NRDS) with gestational age less than 32 weeks were divided into control group (nasal continuous airway positive pressure ventilationplus aminophylline treatment) and observation group (nasal intermittent positive pressure ventilation combined with caffeine treatment).Clinical effect was compared between two groups.Results The incidence rate of complications in the observation group was 16％,which was significantly lower than 32％ in the control group (P ＜ 0.05).There was no significant difference in blood gas indexes between the two groups after treatment of one hour,and the blood gas indexes after treatment of 12 hours in the observation group were significantly better than the control group (P ＜ 0.05).Conclusion Nasal intermittent positive pressure ventilation combined with caffeine can significantly improve the blood gas indexes and reduce the incidence rate of complications in premature infants with extubation failure.