2型糖尿病合并颈动脉粥样硬化的危险因素及血小板与淋巴细胞比和中性粒细胞与淋巴细胞比值分析

摘要

Objective To investigate risk factors of type 2 diabetes mellitus complicated with carotid atherosclerosis and analysis of neutrophil to lymphocyte ratio and platelets to lymphocyte ratio levels.Methods A total of 125 type 2 diabetes patients in our hospital were selected as research objects,including 60 type 2 diabetes cases as control group,and 65 type 2 diabetes mellitus patients complicated with carotid atherosclerosis as observation group,risk factors and NLR,PLR levels of two groups were compared.Logistic regression analysis were used to analyze the risk factors of type 2 diabetes with carotid atherosclerosis.Results No significant differences were observed in BUN,Cr,HDL,UA levels between the two groups (P ＞ 0.05).The observation group had higher SBP,DBP,TG,TC,CRP and LDL,and lower HbA1 c and FPG than the control group,and the differences between the two groups were statistically significant (P ＜ 0.05).The levels of NLR and PLR in the control group were lower than that of the observation group (P ＜ 0.05).Logistic regression analysis showed that elevated levels of LDL,SNP,SBP,NLR and PLR were risk factors of carotid atherosclerosis in type 2 diabetes mellitus patients.Conclusion Carotid atherosclerosis in type 2 diabetes mellitus,SBP,DBP,TG,TC,HbA1c,FPG and CRP are closely related to CRP.%目的 探讨2型糖尿病患者合并颈动脉粥样硬化的危险因素及血小板与淋巴细胞比(PLR)和中性粒细胞与淋巴细胞比值(NLR)水平分析.方法 选择125例2型糖尿病患者,其中60例2糖尿病患者为对照组,65例2型糖尿病合并颈动脉粥样硬化患者为观察组,比较2组患者危险因素及NLR、PLR水平状况,采用Logistic回归分析2型糖尿病合并颈动脉粥样硬化的危险因素.结果 2组患者BUN、Cr、HDL、UA比较无显著差异(P＞0.05),观察组SBP、DBP、TG、TC、CRP与LDL均显著高于对照组(P＜0.05).观察组HbA1c与FPG均显著低于对照组(P＜0.05).对照组NLR、PLR水平显著低于观察组(P＜0.05).Logistic回归分析结果表明,LDL、SNP、SBP、NLR、PLR水平升高是2型糖尿病患者颈动脉粥样硬化的危险因素.结论 2型糖尿病合并颈动脉粥样硬化与SBP、DBP、TG、TC、HbA1c、FPG与CRP密切相关.