高迁移率族蛋白B1在肝脏疾病发生中的作用

摘要

高迁移率族蛋白B1( HMGB1)是含量丰富的非组蛋白染色体结合蛋白,在细胞损伤和炎症反应时可通过主动分泌和被动释放移位到细胞浆和细胞外.近年研究提示HMGBI可作为一种炎症因子和内源性损伤相关分子模式被其受体识别而促进肝脏炎症、损伤和纤维化发生信号,并参与肝脏肿瘤发生和对肿瘤的免疫反应.本文对这些方面的研究进展作一简要综述.%High mobility group box 1 ( HMGB1) is an enriched non - histone, chromatin - associated nuclear protein. During cell damage and inflammation HMCB1 can be extracellularly released by ways of active secretion and passive diffusion. Recent studies shows that HMGB1 may act as an inflammatory factor and an endogenous damage - associated molecular pattern recognized by its receptors, mediates liver inflammation, injury, fibrogenesis, as well as oncogenesis and tumor immune response. This review introduces the structure, function of HMGB1 and its role in human liver diseases.