内分泌腺来源的血管内皮细胞生长因子在人胰腺癌组织中的表达及临床意义

摘要

目的 探讨内分泌腺来源的血管内皮细胞生长因子(EG-VEGF)在人胰腺癌组织中的表达及临床意义.方法 应用免疫组化技术检测EG-VEGF在60例胰腺癌组织和10例正常胰腺组织中的表达情况,并分析其与临床病理因素之间的关系.结果 EG-VEGF在60例胰腺癌组织中的阳性表达率为95％(57/60),而在10例正常胰腺组织中的阳性表达率为10％( 1/10),两者间差异有统计学意义(P＜0.05).EG-VEGF的表达与胰腺癌的临床病理分期以及淋巴结转移呈正相关(P＜0.05),而与性别、年龄、病理分级无明显相关性(P＞0.05).结论 EG-VEGF在胰腺癌的发生发展过程中起着重要作用,可作为判断胰腺癌预后的有用指标.%Objective To investigate the expression of endocrine gland -derived vascular endothelial growth factor ( EG - VEGF) in pancreatic carcinoma and investigate its relation to clinicopathologic features and prognosis of the disease. Methods Immunohistochemical staining tissue microarray was used to detect expression of EG - VEGF in 60 cases of pancreatic carcinoma and 10 cases of normal pancreatic tissues. The clinical significance of EG -VEGF expression in pancreatic cancer was analyzed by the Cochran - Mantel - Haenszel or Fisher's exact test statistical methods. Results The positive rate of EG - VEGF was significantly higher in pancreatic carcinomas (95% , 57/60). Than in normal pancreas tissues ( 10% , 1/10) (P < 0. 05). EG - VEGF protein expression was closely correlated with TNM stage and lymph node metastasis ( both P <0.05). Conclusion High expression of EG - VEGF plays a considerable role in development of pancreatic carcinoma. EG - VEGF may be a useful prognostic marker for pancreatic cancer.