产前应用地塞米松预防早产儿发生呼吸窘迫综合征的临床疗效

摘要

目的 探讨产前应用地塞米松预防早产儿发生呼吸窘迫综合征(RDS)的临床疗效.方法 分析自2008年10月至2010年1月收治的早产儿92例,根据孕妇产前是否给予地塞米松分为:观察组即给予地塞米松组42例,对照组未给予地塞米松组50例,比较两组临床总体疗效,早产儿RDS发生情况,持续呼吸道正压通气(CPAP)使用率及时间和死亡情况.结果 地塞米松组与对照组比较,RDS发生率、CPAP应用率及应用时间均下降,P＜0.05.地塞米松组总有效率为100.0％,对照组总有效率为79.0％,地塞米松组总有效率明显高于对照组(P＜0.05).结论 产前应用地塞米松是预防早产儿发生RDS的有效方法,且能降低CPAP的临床应用及早产儿病死率,值得临床推广使用.%Objective To explore the effect of dexamethasone applied before delivery for preventing neonatal respiratory distress syndrome (RDS). Mestods A total of 92 premature babies in this department during October 2008 to January 2010 were randomly divided into 2 groups, 42 cases in trial group were given with dexamethasone and 50 eases in control group were not given with dexamethasone. The total effective rate and incidence rates of RDS, CPAP and mortality were analyzed and compared. Results The incidence rates of RDS and CPAP in patients of trial group were lower than those of control group ( P < 0.05). Their total effective rates were 100.0% and 79.0% respectively in these two groups ( P <0.05). Conclusion Dexamethasone can significantly reduce the rates of RDS, CAPA and mortality of neonates, and it is worthy to be recommended for clinical application.