常频和高频通气治疗早产儿呼吸窘迫综合征的疗效及安全性分析

摘要

Objective To analyze the efficacy and safety of constant frequency and high frequency ventilation in treatment of neonatal re-spiratory distress syndrome(NRDS). Methods 100 cases of preterm children with NRDS in January 2011 to December 2013 were randomly di-vided into 2 groups,50 cases of which were treated with conventional mechanical ventilation(CMV). These patients were considered as the CMV group. The other 50 cases were treated with high - frequency oscillatory ventilation(HFOV)therapy,who were considered as the HFOV group. The treatment efficiency,oxygen partial pressure(PaO2 ),oxygenation index(OI),partial pressure of carbon dioxide( PaCO2 ),incidence of complications and prognosis of two groups were compared before and after treatment. Results ①The treatment efficiency of the HFOV group after 48 h was 94. 0% ,which was significantly higher than 84. 0% of the CMV group. There was statistical significant difference between the two groups ( P < 0. 05). ②PaO2 ,OI,PaCO2 levels in the HFOV group after 8 h,24 h,48 h of treatment were improved significantly than the CMV group. The difference was statistically significant( P < 0. 05). ③HFOV group of chronic lung disease,the incidence of pneumothorax was significantly lower than the CMV group. The difference was statistically significant( P < 0. 05). HFOV group,the cure rate was 98. 0% ,which was signifi-cantly higher than the 90. 0% CMV group. The difference was statistically significant( P < 0. 05). Conclusion High frequency ventilation has a significant curative effect in treatment of premature infants with respiratory distress syndrome,with higher safety.%目的：分析常频和高频通气治疗早产儿呼吸窘迫综合征（NRDS）的疗效及安全性。方法选择2011年1月至2013年12月早产 NRDS 患儿100例，随机分为两组。50例采用常频机械通气（CMV）治疗（CMV 组），另50例采用高频震荡通气（HFOV）治疗（HFOV 组）。比较两组患儿治疗有效率、治疗前后氧分压（PaO2）、氧合指数（OI）、二氧化碳分压（PaCO2）、并发症发生率及转归。结果①HFOV 组治疗48 h 后有效率为94.0%，明显高于 CMV 组的84.0%，差异有统计学意义（ P <0.05）。②HFOV 组治疗8 h、24 h、48 h 后 PaO2、OI、PaCO2水平较 CMV 组改善明显，差异有统计学意义（ P <0.05）。③HFOV 组慢性肺疾病、气胸发生率明显低于 CMV 组，差异有统计学意义（ P <0.05）。HFOV 组治愈率为98.0%，明显高于 CMV 组的90.0%，差异有统计学意义（ P <0.05）。结论高频通气治疗早产儿呼吸窘迫综合征疗效显著，安全性较高。