目的 探讨2型糖尿病(T2DM)患者肾脏尿酸排泄水平与糖化血红蛋白(HbA1c)水平的相关性.方法 根据HbA1c水平将2015年1~10月住院的367例T2DM患者分为三组(A组HbA1c≤7%、B组7%9%),校正各组性别、年龄、病程、体质指数等一般资料后,比较HbA1c、血脂、血尿酸(SUA)、尿微量白蛋白(UA1b)、尿总蛋白(UTP)、尿肌酐(Ucr)、尿尿酸(UUA)、空腹血糖(FPG)、餐后2 h血糖(2 hPG)、空腹胰岛素(Fins)、胰岛素抵抗指数(HOMA-IR)及餐后2 h胰岛素(2 hIns)、尿酸排泄分数(FEUrea)等生化指标.结果 ①B组SBP、DBP和2 hPG均高于其他两组;随着HbA1c水平升高,A、B、C三组的FPG、eGFR、FEUrea水平依次增加,而2 hIns、SUA水平依次下降(P均0.05).②单因素方差分析结果显示:FEUrea与HbA1c、FPG、2 hPG呈正相关,FEUrea与2 hlns、SUA呈负相关(P9%)according to HbA1c levels. Biochemical indicators were collected and analyzed after correcting clinical data among three groups. The levels of HbA1c,lipids,uric acid (SUA),urinary albumin (UA1b)and urinary total protein (UTP),Urinary creatinine (Ucr),uric acid (UUA), fasting plasma glucose (FPG),postprandial 2 h blood glucose (2 hPG),fasting insulin (Fins),insulin resistance index (HOMA-IR)and 2 h postprandial insulin (2 hIns),uric acid excretion fraction (FEUrea)and other biochemical indicators were compared. Results ①Eight projects of biochemical indicators were statistically difference,which were SBP,DBP,FPG,2 hPG,2 hlns,SUA,eGFR and FEUrea (P < 0. 05). ②One-way analysis of variance showed that the level of FEUrea and HbA1c,FPG,2hPG had positive correlation,but it had negative correlation with 2 hlns and SUA (P < 0. 05). ③Multiple linear regression analysis indicated that FEUrea and HbAlc had positive correlation,but it had neg-ative correlation with SUA and eGFR (P < 0. 05). Conclusion The levels of renal uric acid excretion are associated with HbA1c,therefore the FEUrea can become a clinical predictor of T2DM.
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