目的 探讨扭曲基因(Twist)蛋白、p53蛋白在成釉细胞瘤中的表达水平及与病理特征的关系.方法 选取2014年2月至2017年3月病理科保存的成釉细胞瘤标本57例(观察组),选用牙源性角化囊肿40例作为对照组.采用免疫组化染色法检测Twist和p53表达情况.观察比较两组患者Twist和p53蛋白阳性表达率,分析Twist和p53蛋白表达与临床病理特征的关系及Twist与p53蛋白表达的相关性.结果 观察组Twist和p53蛋白阳性表达率为80.70%和71.93%,明显高于对照组的5.00%和7.50%,差异有统计学意义(P 0.05);单囊型成釉细胞瘤Twist阳性表达率为47.06%,明显低于滤泡型和丛状型的95.24%和94.74%,差异有统计学意义(P 0.05);Twist与p53蛋白呈正相关(r s=0.288,P 0.05). The positive rate of Twist expression in single cystic ameloblastoma was 47.06%,which were significantly lower than that of follicular and plexiform type 95.24% and 94.74%(P 0.05). There was a positive correlation between Twist and p53 protein(r s=0.288,P <0.05). Conclusion Twist is highly expressed in ameloblastoma,and its expression is related to pathological classification and apoptosis protein p53,and deserves further study.
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