参麦注射液改善兔休克再灌注期间肠道灌注及氧合

摘要

目的：研究参麦注射液(SM)对休克再灌注期间肠道灌注及氧合的影响。方法：21只兔随机分为对照组(Ⅰ组，n=6)，休克再灌注组(Ⅱ组，n=9)及SM治疗组(Ⅲ组，n=6)。采用Lamson休克再灌注模型，通过Tonometry张力计及门静脉置管，观察休克前、休克1小时、再灌注1和2小时乙状结肠肠粘膜pH(pHi)、门静脉血气及血流动力学变化。结果：Ⅱ组再灌注期间pHi及门静脉血pH(pHpv)持续低于Ⅰ组(P<0．05)及休克前(P<0．01)，且二者线性相关；而门静脉血氧饱和度(SpvO2)高于Ⅰ组，与pHi呈负相关。Ⅲ组再灌注1和2小时pHi及pHpv较Ⅱ组明显升高(P<0．05)，而SpvO2恢复至Ⅰ组水平。Ⅲ组再灌注期间MAP及CO高于Ⅱ组，而外周血管阻力(SVR)低于Ⅱ组(P<0．05)。Ⅱ组除再灌注1小时MAP外各指标与Ⅰ组无差异。结论：SM能明显改善休克再灌注期间肠道血液灌注及氧合。%Objective: To investigate the effects of Shen-Mai injection(SM) on perfusion and oxygenation of intestinaltract during repeffusion in shocked rabbits. Methods:Twenty-one rabbits were divided into control group (Ⅰ,n = 6), shock-repeffusion group ( Ⅱ, n = 9) and SM group ( Ⅲ, n = 6). Intestinal intramucosal pH (pHi) of the sigrnoid colon and portalvein blood gas was observed before shock, at 1 hour after shock, 1 hour and 2 hours of reperfusion. Results: pHi and portal vein pH in group Ⅱ were significantly lower than those in group Ⅰ (P < 0.01), but portal vein increased obviously during reperfusion. There was a good linear positive correlation between pHi and portal vein pH. Portal vein in group Ⅱ wasrngreater than that in group Ⅰ and had anegative correlation with pHi. pHi and portal vein pH of group Ⅲ increased signifi-rncantly compared with those of goup Ⅱ ( P < 0.05), while of group Ⅲ returned to the level of group Ⅰ . MAP and CO of group m were higher than those of group Ⅱ after 1 hour or 2 hours reperfusion (P<0.05).CO of group m remained at a high level during reperfusion. But SVR of group Ⅲ was lower than that of group Ⅱ during reperfusion. Conclusion: SM im-proves perfusion and oxygenation of intestinal tract during reperfusion.