灵龟八法联合温胃贴治疗腹泻型肠易激综合征临床研究

摘要

目的:观察灵龟八法联合温胃贴治疗腹泻型肠易激综合征 (脾肾阳虚型) 的疗效.方法:将60例患者按随机数字表法分为治疗组 (灵龟八法联合温胃贴) 和对照组 (马来酸曲美布汀分散片), 每组30例, 疗程为4周, 分别采用IBS症状严重程度量表 (IBS bowel symptom severity scale, IBS-BSS)、IBS大便性状问卷 (IBS defecation state questionnaire, IBS-DSQ) 和IBS生活质量问卷 (IBS quality of life questionnaire, IBS-QOL) 评估两组患者治疗后总体临床疗效、大便性状情况及生活质量.结果:治疗组IBS-BSS总有效率为93. 3％, 优于对照组的76. 7％ (P＜0.05), IBS-BSS各项积分及总积分比较, 治疗组低于对照组 (P＜0.05);治疗组大便性状总有效率为90.0％, 优于对照组的73. 3％ (P＜0.05), 且治疗组在每天排便次数及10天中排便的急迫天数方面均优于对照组 (P＜0.05);治疗组在睡眠状态、精力改变、日常运动、日常社交、工作影响项目方面积分及IBS-QOL总积分方面优于对照组 (P＜0.05) .结论:灵龟八法联合温胃贴治疗腹泻型肠易激综合征 (脾肾阳虚型) 能缓解临床症状, 提高排便满意度和改善患者生活质量, 值得临床广泛推广.%Objective: To explore the clinical efficacy of Linggui Bafa acupuncutre combined with Wenwei Paste in the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D) with yang-deficiency of Spleen and Kidney. Methods: 60 cases of IBS-D were randomized into the observation group (n = 30) and the control group (n = 30). The observation group was treated with Linggui Bafa acupuncutre combined with Wenwei Paste;the control group was treated with Trimebutine Maleate Dispersible Tablets. The treatment duration was four weeks. The total effective rate, the stool property, and the quality of life were assessed by IBS bowel symptom severity scale (IBS-BSS), IBS defecation state questionnaire (IBS-DSQ), and IBS quality of life questionnaire (IBS-QOL) after the treatment. Results: The total improvement rate of IBS-BSS was 93. 3％ in the observation group, which was significantly higher than 76. 7％ in the control group (P ＜ 0. 05); the observation group was superior to the control group in each score and integral score of IBS-BSS (P ＜ 0. 05). The total effective rate of improving the stool property was 90. 0％ in the observation group, which was greatly higher than73. 3％ in the control group (P ＜ 0. 05); the observation group was superior to the control group in terms of daily times of defecation and the number of days for emergent defecation among 10 days (P ＜ 0. 05). The observation group was better than the control group in sleep status, energy improvement, daily exercise, daily social interaction, work impact and total IBS-QOL score (P ＜ 0. 05). Conclusion: Linggui Bafa acupuncutre combined with Wenwei Paste can relieve clinical symptom, improve defecation satisfaction and improve QOL of the patients in the treatment of IBS-D with yang-deficiency of Spleen and Kidney, which is worthy of wide clinical promotion.