天枢穴药物敷贴联合硬膜外镇痛泵对痔疮术后疼痛患者VAS评分及血清β－内啡肽的影响

摘要

Objective:To observe the effect of VAS score and serum β-endorphin on post -operation pain of hemorrhoids by application at Tianshu combined with epidural analgesia pump .Methods:Sixty cases were ran-domly divided into a treatment group and a control group ,with thirty cases in each group .The treatment group received the application at tianshu combined with epidural analgesia pump ,and the control group received epi-dural analgesia pump .Both groups received the postoperative routine treatment .Their VAS score and serum β-endorphin were observed and analyzed comparatively .Results:The VAS score of both groups were increased in 2 h,6 h,24 h,48 h after haemorrhoidectomy compared with that 30 minutes before haemorrhoidectomy ( P <0.05).The treatment group was lower than the control group in 24 h,48 h after haemorrhoidectomy,and there was a statistical difference between two groups (P<0.05),but there was no statistical difference between two groups in 2 h,6 h after haemorrhoidectomy ( P>0 .05 );the serum β-endorphin of both groups was descended in 24 h,48 h after haemorrhoidectomy .The treatment group was higher than the control group ,and there was a statistical difference between two groups ( P<0 .05 ) .Conclusion:Application at Tianshu combined with epi-dural analgesia pump can effectively relieve post -operation pain of hemorrhoids ,and its mechanism may be re-lated to the increase of serum β-endorphin .%目的：探讨天枢穴药物敷贴联合硬膜外镇痛泵对痔疮术后疼痛患者VAS评分及血清β－内啡肽的影响。方法：将60例患者按随机数字表法分为观察组和对照组，每组30例。观察组予天枢穴药物敷贴联合硬膜外镇痛泵，对照组予硬膜外镇痛泵，且两组术后予常规处理。观察治疗前后的VAS评分及血清β－内啡肽含量，进行对比分析。结果：术后2 h、6 h、24 h、48 h两组的VAS评分较本组术前30 min均升高（P＜0．05），术后24 h、48 h两组间的VAS评分比较，观察组低于对照组，差异有统计学意义（P＜0．05），而术后2 h、6 h两组间的VAS评分比较，差异无统计学意义（P＞0．05）；术后24 h、48 h两组的血清β－内啡肽含量较本组术前均降低（P＜0．05），组间比较观察组高于对照组，差异有统计学意义（P＜0．05）。结论：天枢穴药物敷贴联合硬膜外镇痛泵能有效缓解痔疮术后疼痛，其作用机制可能是血清β－内啡肽含量升高，进而达到镇痛作用。