Hypedipidemia has high morbidity. We explored the novel activities of six Chinese herbs before and after fermentation for preventing hyperlipidemia. The herbs were fermented with white rot fungi Ganoderma lucidum, a strain of EN2. Lovastatin was used as the positive control. Mice were treated with those herbs before and after fermentation treatment for 15 d and then injected peritoneally with Triton 3393. After the treatment, the serum total cholesterol (TC) and triglyceride (TG) were measured. More-over, the changes of the ingredients of those herbs were analyzed by fingerprint chromatography. The results showed that Herba leonuri before fermentation, Ramulus mori and Caulis lonicerae after fermentation, Radix sophorae flavescentis before and after fermentation showed activities to prevent hypertriglyceridemia, while Ramulus mori and Herba leonuri before fermentation showed activities to prevent hypercholesterolemia. In addition, some new ingredients were appeared after fermentation. In conclusion, the novel activities of these herbs to prevent hyperlipidemia were identified and the new ingredients that emerged after fermentation warrant further exploration.%高血脂具有高致病性.本文通过比较中药发酵前后降血脂变化来探讨6味中药功效的变化.64中药采用白腐菌灵芝发酵,分成不同动物实验组,采用洛伐他江为阳性对照药.小鼠在连续用药15天后,腹腔注射Triton 3393,然后检测血清总胆固醇和总甘油三酯,并对部分中药发酵前后的HPLC指纹图谱进行了比较.结果显示益母草发酵前,桑枝和藤金银花发酵后,苦参发酵前后均能降低甘油三酯,而桑枝和益母草发酵前可以降低胆固醇含量.同时通过高效液相色谱分析发现一些新成分在发酵后产生.因此,白腐菌发酵提高了部分中药降血脂功效,并产生一些新的物质,表明中药通过一些药用真菌发酵提高或改变功效的方法值得进一步探讨研究.白腐菌发酵中药功效变化研究值得进一步探索.
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