Microarray expression analysis of epithelial ovarian cancer with distinct differentiation

摘要

To identify gene expression profiling in epithelial ovarian cancer and to explore its correlation with histopathology characterization and prognosis.Gene expression profiles were generated from 10 hu- man ovarian frozen tissue specimens using Agilent Human 1A microarrays.Strikingly.clear differences of gene expression patterns were observed in ovarian cancer as compared to normal tissues.Unique gene pro files were observed in moderately and poorly differentiated epithelial ovarian cancer.It is concluded that different histopathology characterization likely exists extensive molecular heterogeneity.