沈阳市城区正常儿童肺功能预测方程研究

摘要

目的：建立沈阳市健康儿童肺功能预测方程。方法采用整群随机抽样法在沈阳市5个行政区各抽取1所小学和1所初中，将10所学校三年级到九年级所有儿童作为研究对象。身高、体质量和肺功能指标按照标准化程序由经过培训的调查员进行测量。应用线性回归模型建立不同性别的肺功能预测方程。结果在调查的1087例儿童中，除年龄外其他指标[身高、体质量、用力肺活量（FVC）、一秒用力呼气容积（FEV1）、最大呼气中期流量（MMEF）和最大呼气流速峰值（PEF）]在不同性别组间均具有统计学差异（P<0.05）。不同性别的FVC、FEV1、MMEF和PEF（因变量）等肺功能指标与年龄、身高和体质量（自变量）之间的回归预测方程具有较好的拟合优度。结论本研究建立了沈阳市城区9~15岁儿童肺功能预测方程。%Objective To develop accurate predictive equations for spirometric reference values for children aged 9 to 15 years in Shenyang. Meth-ods A cross-sectional study of healthy children was conducted at 10 randomly selected schools in Shenyang city. Weight,height and spirometry measurements of 1 087 school children were measured by trained interviewers. Prediction equations were developed using the multiple linear regres-sion. The independent variables were entered in sequence of height,age and weight. R2 and estimates of regression coefficients were obtained and the goodness of fit was examined. Results There were significant differences on the lung function between different gender,height,and weight groups. The prediction equations showed good performance for most spirometric parameters. Conclusion Prediction equations for spirometric parameters was developed,which is applicable to the chinese children within the age range of 9-15 year-old.