目的:评价MSCT定量成像参数与常规肺功能参数相关性,分析COPD患者与正常志愿者MSCT定量参数的对比性,确定COPD患者MSCT定量成像参数的临床可行性.方法:正常志愿者30例,COPD患者40例,通过常规肺功能检查及MSCT检查,在最大吸气末及最大呼气末屏气扫描,所有数据通过肺计算机辅助检查系统软件进行分析,所得数据与肺功能检查(PFf)进行相关性分析并与正常志愿者数据进行分析比较.结果:COPD患者最大呼气容积/最大吸气容积(Vex/Vin)与残气量/肺总量(RV/TLC)有显著的相关性(r=0.90,P<0.01),Vin和Vex与TLC及RV亦有很好的相关性(r分别为0.70和0.81,P<0.01),(Vin-Vex)与FVC亦有很好的相关性(r=0.76,P<0.01).深呼气相时EV-91,与FEV1/FVC%有很好的相关性(r=-0.84,P<0.01).PI-91lin、PI-950in、及PI-910ex、PI-950ex与FEV1及FEV1/FVC%均有很好的相关性,以呼气相时的相关性更好,其中以PI-910ex时的相关性为佳(r分别为-0.86和-0.85,P<0.01).深吸气末肺容积为(5318.151±1200.74)ml,平均肺密度为(-898.04±35.36)HU,单位体积密度为(0.102±0.035)g/cm3,三者与正常志愿者之间无统计学意义(P值均>0.01).深呼气末肺容积为(3878.21±1202.75)ml,平均肺密度为(-855.04±50.41)HU,单位体积密度为(0.144±10.051)g/cm3,与正常志愿者之间有统计学意义(P值均<0.01).结论:MSCT肺功能检查能很好的评估COPD患者的情况,可为临床诊断提供客观的依据.%Objective: To correlate MSCT pulmonary function parameters and pulmonary function test parameters. To compare quantitative parameters of MSCT between COPD patients and normal volunteers, and to define the clinical feasibility parameters of MSCT in patients with COPD. Materials and Methods: Thirty cases of normal control group, forty cases of COPD with clinical pulmonary function test and MSCT scan at the end of the maximum inspiratory and maximum expiratory phase. All data was analysed by the lung analysis software of computer-aided inspection system, correlation analysis with pulmonary function parameters and comparison of the normal volunteers were made. Results: There was significant correlation with Vin/Vex and residual volume(RV)/total lung capacity(TLC)(r=0.90, P＜0.01). There was significant correlation with Vin, Vex and TLC, RV (r=0.70, 0.81, respectively, P＜0.01). (Vin-Vex) showed correlation with FVC (r=0.76, P＜0.01). Expiratory EV-910 correlated with FEV1/FVC％(r=-0.84, P＜0.01). Expiratory PI-910 had a good correlation with FEV1 and FEV1/FVC％(r=-0.86, -0.85,respectively, P＜0.01). At inspiratory phase, the average Vin was (5318.15±1200.74)ml, lung density was (-898.04±35.36)HU,the density per unit volume was (0.102±0.035)g/cm3. There was no significant difference among the three parameters in normal group and COPD group(P＞0.01). At expiratory phase, the average Vex was (3878.21±1202.75)ml, lung density was (-855.04±50.41)HU, the density per unit volume was (0.144±0.051)g/cm3. There was significant difference among the three parameters in normal group and COPD group (P＜0.01). Conclusion: MSCT pulmonary function test can evaluate the situation and provide an objective basis for clinical diagnosis of the patients with COPD.
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