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Bromocriptine enhances the uptake of 99mTc-MIBI in patients with hepatocellular carcinoma

机译:溴隐亭可提高肝细胞癌患者99mTc-MIBI的摄取

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摘要

99m Tc-methoxyisobutyl isonitrile(MIBI) is a suitable transport substrate for the multidrug resistance gene product P-glycoprotein(P-gp) and widely used for tumor imaging.Bromocriptine has been shown to inhibit the ATPase activity and the function of P-gp.We hypothesized that bromocriptine could promote the accumulation of MIBI by inhibiting P-gp activities,a feature that can be taken advantage of for enhancing 99mTc-MIBI imaging.In the current study,we sought to investigate whether bromocriptine enhanced the uptake of 99mTc-MIBI in hepatocellular carcinoma patients.Sixty primary hepatocellular carcinoma patients received 99mTc-MIBI single photon emission computer tomgraphy(SPECT) prior to surgery.99mTc-MIBI SPECT was performed 15 and 120 min after injection of 20 mCi 99mTc-MIBI,and early uptake,delayed uptake(L/Nd),and washout rate(L/Nwr) of 99mTc-MIBI were obtained.In addition,a second 99mTc-MIBI SPECT was performed according to the same method 48 h after bromocriptine administration.We found that,prior to bromocriptine administration,significant MIBI uptake in tumor lesions was noted in only 10(16.7%,10/60) patients with hepatocellular carcinoma.No significant MIBI uptake was observed in the tumor lesions of the remaining 50(83.3%,50/60) hepatocellular carcinoma patients.Following bromocriptine administration,all the patients without apparent MIBI uptake demonstrated significant MIBI uptake on 99mTc-MIBI SPECT(P < 0.05).Our findings indicate that bromocriptine enhances the uptake of 99m Tc-MIBI in patients with hepatocellular carcinoma.

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  • 来源
    《生物医学研究杂志(英文版)》 |2012年第3期|165-169|共5页
  • 作者单位

    Department of Internal Medicine,Jiaonan People's Hospital of Shandong Province,Jiaonan,Sbandong 266400,China;

    Department of General Surgerg,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China;

    Department of General Surgerg,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China;

    Department of General Surgerg,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China;

    Department of General Surgerg,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China;

    Department of General Surgerg,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China;

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  • 入库时间 2022-08-19 03:48:01
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