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PET imaging for receptor occupancy: meditations on calculation and simplification

机译:用于受体占用的PET成像:对计算和简化的沉思

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摘要

This invited mini-review briefly summarizes procedures and challenges of measuring receptor occupancy with positron emission tomography. Instead of describing the detailed analytic procedures of in vivo ligand-receptor imaging, the authors provide a pragmatic approach, along with personal perspectives, for conducting positron emission tomography imaging for receptor occupancy, and systematically elucidate the mathematics of receptor occupancy calculations in practical ways that can be understood with elementary algebra. The authors also share insights regarding positron emission tomography imaging for receptor occupancy to facilitate applications for the development of drugs targeting receptors in the central nervous system.

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  • 来源
    《生物医学研究杂志(英文版)》 |2012年第2期|69-76|共8页
  • 作者

    Yumin Zhang; Gerard B. Fox;

  • 作者单位

    Translational Sciences, Global Pharmaceutical R & D, Abbott Laboratories, Abbott Park, IL 60064, USA;

    Translational Sciences, Global Pharmaceutical R & D, Abbott Laboratories, Abbott Park, IL 60064, USA;

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  • 入库时间 2022-08-19 03:48:01
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