分子绝对进化速率与物种分歧时间之间的定量关系

摘要

By studying some protein and nucleotide sequences available from GenBank database in American National Center of Bio -technology Information (NCBI), a quantitative equation was discovered for the relationship between the absolute molecular evolutionary Ea rates and taxa divergence times as follow:lnk =-Rt +lnK0 , where Ea is the activation energy of locus mutation , k0 is extreme absolute molecular evolutionary rate , and R is a constant , its preliminary biological application was discussed .Data analysis also showed that a similar equation is also applicable for the relationship between extreme absolute molecular evolutionary rates and taxa divergence times , which means that the biological molecular evolution process may be under the control of "molecular o′clocks"of sequence locus muta-tion and evolution of taxa extreme molecular evolutionary rates , which can be called as "dual molecular o′clock".%通过对美国国家生物技术信息中心数据库GenBank提供的一些蛋白质和核苷酸序列进行比对和分析，发现生物分子绝对进化速率k与进化时间或物种分歧时间t之间存在下列定量关系：lnk ＝－Ea Rt ＋lnK0，式中Ea为位点突变活化能，k0为分子极限绝对进化速率，R为常数，并对其生物学意义进行了初步的探讨；数据分析还揭示出物种的分子极限绝对进化速率与进化时间或物种分歧时间之间也服从相似的定量公式，也就是说生物分子进化过程可能同时受到序列位点突变和控制物种分子极限绝对进化速率进化的两个“分子钟”作用，即存在“双重分子钟”现象。