eIF4E和CyclinD1在子宫内膜增生症和子宫内膜样腺癌中的表达及其意义

摘要

Objective: To study the expression and clinical significance of eIF4E and CyclinDl in endometrial hyperplasia and endometrial carcinoma. Methods: The expressions of eIF4E and CyclinDl in 40 cases of simple hyperplasia, 40 cases of complex hyperplasia( 25 cases of atypical hyperplasia) ,65 cases of endometrial carcinoma and 15 cases of normal proliferative endometrium were detected by means of immunohistochemical EliVision, the related pathological parameters were analyzed. Results: The positive expression of eIF4E in normal proliferative endometrium, simple endometrial hyperplasia, complex endometrial hyperplasia, atypical hyperplasia and endometriod adenocarcinoma was 53. 33% ,72. 50% ,80. 00% ,84. 00% and 90. 77% ,respectively; while the positive expression of CyclinDl was 6. 67% ,52. 50% ,70. 33% , 80. 00% and 81. 54% , respectively. The expression of eIF4E was only significantly different between the endometrial carcinoma and the normal proliferative endometrium ( P0. 05) . Statistical analysis showed that there was a positive correlation between eIF4E and CyclinDl expression in endometriod adenocarcinoma (P 0.05).在子宫内膜样腺癌中,eIF4E、CyclinD1表达呈正相关关系(P<0.01).结论:eIF4E、CyclinD1在子宫内膜样腺癌中均高表达,两者的异常表达共同作用促进子宫内膜样腺癌的发展,两者有协同作用.